Journal article
Simulating lifetime outcomes associated with complications for people with type 1 diabetes
TWC Lung, PM Clarke, AJ Hayes, RJ Stevens, A Farmer
Pharmacoeconomics | ADIS INT LTD | Published : 2013
Abstract
Objectives: The aim of this study was to develop a discrete-time simulation model for people with type 1 diabetes mellitus, to estimate and compare mean life expectancy and quality-adjusted life-years (QALYs) over a lifetime between intensive and conventional blood glucose treatment groups. Methods: We synthesized evidence on type 1 diabetes patients using several published sources. The simulation model was based on 13 equations to estimate risks of events and mortality. Cardiovascular disease (CVD) risk was obtained from results of the DCCT (diabetes control and complications trial). Mortality post-CVD event was based on a study using linked administrative data on people with diabetes from ..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This report is independent research commissioned by the National Institute for Health Research Health Technology Assessment (NIHR HTA) programme (Project Number 08/67/03). The views expressed in this publication are those of the authors and not necessarily those of the UK NHS, the NIHR or the Department of Health (UK). In regard to other funding, P.M.C. was funded from an Australian National Health and Medical Research Council (NHMRC) Career Development Award (571122). T.W.C.L. was partially funded from a NHMRC Capacity Building Grant (571372) and an NHMRC Project Grant (1028335). A.J.H. was supported by an NHMRC Capacity Building Grant (571372). A.F. receives support from the NIHR Oxford Biomedical Research Centre.